Stochastic threshold in cell size control

Classic models of cell size control consider that cells divide when reaching a threshold, e.g., size, age, or extension. The molecular basis the threshold involves multiple layers regulation as well gene noise. In this paper, we study cycle first-passage problem with stochastic and discover such stochasticity affects intergeneration statistics, which bewilders criteria to distinguish types models. analytic results show autocorrelation in can drive sizer model adderlike even timerlike is supported by simulations. Following picture propagate further adder be driven one positively autocorrelated sizerlike negatively autocorrelated. This work highlights importance examining noise control.